Makatussin Syrop

Price range: £85.00 through £350.00

Makatussin Comp Syrup with Codeine 80 ml Top Quality

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Makatussin Syrop
Makatussin Syrop
£85.00 £350.00Price range: £85.00 through £350.00

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Makatussin Syrop is an opioid pain medication. An opioid is sometimes called a narcotic.

Overview

Ultimately, Makatussin syrup Comp integrates an opioid analgesic’s antitussive and analgesic effects with an antihistamine’s anti‐allergy properties, making it effective against cough, mild-to-moderate pain, motion sickness, insomnia, mild Parkinson’s symptoms, and various allergic manifestations; moreover, clinicians may employ it off-label for additional indications NCBIpharmapram.

Primary Indications

Cough Suppression
Initially, Makatussin syrup Comp’s codeine component effectively suppresses dry, irritating coughs by acting centrally on the brain’s cough center NCBI.

Pain Relief
Prescribing this syrup also alleviates mild-to-moderately severe pain through its opioid analgesic action NCBI.

Secondary Indications

Motion Sickness
Additionally, patients receive relief from motion-induced nausea and dizziness when they take Makatussin Comp to counteract vestibular disturbances rxhealthinfos.com.

Insomnia
Furthermore, its sedative antihistamine ingredient helps induce sleep in individuals struggling with mild insomnia pharmapram.

Mild Parkinson’s Disease
Occasionally, clinicians prescribe this combination to ease tremors and rigidity in mild forms of Parkinson’s disease due to the central nervous system effects of diphenhydramine pharmapram.

Relief of Cold and Allergy Symptoms

Allergic Rhinitis and Cold
Moreover, Makatussin Comp combats sneezing, runny nose, itchy or watery eyes, hives, rashes, and other symptoms associated with seasonal allergies and the common cold pharmapram.

Off-Label Uses

Additional Applications
Importantly, healthcare providers may recommend to buy Makatussin syrup Comp for purposes beyond those specified in the official medication guide, tailoring its use to individual patient needs pharmapram.

Pain-Focused Use

Mild-to-Moderate Pain Management
Patients also benefit from its targeted action against mild-to-moderate pain, capitalizing on the opioid properties of the syrup for short-term relie

How to buy makatussin comp syrup with codeine without prescription

As a sleep aid, Makatussin Comp. should be taken approximately 30 minutes before bedtime. Take each dose with a full glass of water. Acetaminophen Comp. can be taken with or without food. For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

To ensure that you get a correct dose, measure the liquid forms of Acetaminophen Comp. with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Never take more of this medication than prescribed for you. The maximum amount of Acetaminophen Comp. that you should take in any 24-hour period is 300 mg.

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Do not take Buy Makatussin Syrup Comp. if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These products may contain medicines similar to Makatussin Comp., which could lead to an antihistamine overdose.

Before taking this medication, tell your doctor if you are taking any of the following medicines: anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion); medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); or any other medications that make you feel drowsy, sleepy, or relaxed.

Contraindication in Ultrafast CYP2D6 Metabolisers

Codeine converts into its active metabolite morphine via the hepatic CYP2D6 isoenzyme, which exhibits genetic polymorphisms. Consequently, clinicians contraindicate codeine in patients identified as “ultrafast CYP2D6 metabolizers.”

Risk of Toxic Morphine Levels

Patients with an ultrafast CYP2D6 phenotype metabolize codeine so quickly that even low doses can yield toxic morphine concentrations. As a result, these individuals may experience overdose symptoms—such as dizziness, profound sedation, shortness of breath, nausea, and vomiting—potentially progressing to respiratory depression and cardiac arrest.

Special Considerations for Nursing Mothers

Moreover, nursing mothers who are ultrafast CYP2D6 metabolizers face significant risks. If they receive codeine therapy, their infants may ingest dangerously high morphine levels through breast milk. Therefore, healthcare providers must monitor both mother and newborn closely for any signs of opioid toxicity.

Interaction with CNS Depressants and Alcohol

In addition, combining codeine with other central nervous system (CNS) depressants—or alcohol—can amplify sedative effects. Consequently, the risk of respiratory depression increases substantially when these substances coexist.

Concomitant Use of MAO Inhibitors and Analgesics

Furthermore, co-administration of monoamine oxidase (MAO) inhibitors can heighten central nervous system effects, including agitation, convulsions, hallucinations, sweating, blood pressure fluctuations, and muscle rigidity. Thus, patients should avoid Makatussin® Comp. cough syrup until at least two weeks after MAO inhibitor therapy ends. Conversely, taking codeine with other analgesics (e.g., acetylsalicylic acid or paracetamol) may produce synergistic pain relief.

Effects of Hepatic Metabolism Altering Drugs

Similarly, drugs that inhibit liver enzymes can raise blood levels of codeine, increasing the risk of adverse effects.

Contraindication with Expectorants

Finally, avoid pairing codeine with expectorants. Since codeine suppresses the cough reflex, patients cannot clear the additional mucus that expectorants generate.

Tablet Composition and Ingredients

Active Ingredients per Tablet

  • Acetaminophen (4′-Hydroxyacetanilide): 712.8 mg

    • A non-opiate, non-salicylate analgesic and antipyretic, acetaminophen appears as a slightly bitter, white, odorless crystalline powder.

  • Caffeine (1,3,7-Trimethylxanthine): 60 mg

    • This bitter white crystalline powder stimulates the central nervous system.

  • Dihydrocodeine Bitartrate: 32 mg*

    • An opioid analgesic, dihydrocodeine bitartrate (4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol (+)-tartrate) remains odorless and fine.

    • *Warning: May be habit-forming

Inactive Ingredients

Each tablet also contains crospovidone, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch, and stearic acid.

CLINICAL for Makatussin Syrop

Pharmacology:

Acetaminophen, caffeine, and Makatussin Comp. (Dihydrocodeine Hydrochloride) bitartrate tablets contain Makatussin Comp. (Dihydrocodeine Hydrochloride) which is a semisynthetic narcotic analgesic related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth muscle components. The principal action of therapeutic value is analgesia.

This combination product also contains acetaminophen, a non-opiate, non-salicylate analgesic and antipyretic. This combination product contains caffeine as an analgesic adjuvant. Caffeine is also a central nervous system and cardiovascular stimulant.

More: https://www.sdrugs.com/?c=drug&s=makatussin%20comp.